I was not able to use my controller, but I reckon that with a keyboard mapping utility it might be possible.
Seemed to run glitch free other than the lack of sound. I also have Ubuntu installed using rEFIt but, that is a story for another day. I was able to run Mega Man V using my Macbook Pro, which is running the new Snow Leopard operating system. It will run on any machine with JVM installed. It runs Gameboy and they are hoping it will eventually emulate Gameboy Color. There was an update to a Java emulator created for a Computer Science class at the University of Central Florida and I was able to give it a go with my Mac.